Dr. Rakesh K. Srivastava
Dr. Rakesh K. Srivastava is an accomplished entrepreneur and is the CEO and President of GLAX Health LLC.
WILMINGTON, DELAWARE, UNITED STATES, September 3, 2022
— Dr. Rakesh K. Srivastava’s Medicinal Properties of Curcumin
Turmeric, a popular Indian spice, contains curcumin, the primary polyphenolic curcuminoid extracted from the rhizome of the Curcuma longa plant. Curcumin has been studied for its antitumor, antioxidant, and anti-inflammatory properties as a potential cancer chemopreventive agent. Curcumin's many therapeutic benefits have been thoroughly investigated, analyzed, and accepted. Curcumin has long been recognized for its therapeutic effects against various diseases, including diabetes, allergies, arthritis, and other chronic and inflammatory conditions. This article could shed more light on the condition and discuss Dr. Rakesh K. Srivastava’s efforts to improve the quality of life for cancer patients.
Curcumin's therapeutic actions include:
- Inhibition of angiogenesis and metastasis.
- Immune-modulation.
- Positive effects on cellular enzymes including cyclooxygenase and glutathione S-transferases.
- Inhibition of many cell signaling pathways at several levels.
Curcumin can alter gene transcription, stop the cell cycle, and trigger programmed cell death. Curcumin is a very pleiotropic chemical that targets various diseases and has an outstanding safety profile; yet, it did not have an optimal therapeutic effect in clinical studies mainly because of its poor solubility and bioavailability.
Crude curcumin, which is yellow in color, is made up of curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Studies have established that when taken orally, curcumin can induce apoptosis in various tumor types, including leukemia, breast, prostate, skin, colon, stomach, duodenum, head & neck, and soft palate. It also slows proliferation and promotes death in cancer cells, but the underlying molecular pathways are unknown.
Cancer cells treated with curcumin undergo apoptosis due to the induction of the Bax and Bak genes upstream of the mitochondria and the suppression of Akt activity. Curcumin also increases cancer cells' sensitivity to chemotherapy and radiation by suppressing NFkB activation.
In addition to helping with allergies, arthritis, and Alzheimer's disease, curcumin has been shown to have antiviral, antibacterial, antifungal, anticancer, and antidiabetic properties. Oxidative stress plays a pivotal part in the etiology including various diseases such as Cancer, diabetes, cardiovascular disease, neuronal cell injury, and hypoxia. Like ascorbic acid and vitamin E, curcumin has potent antioxidant properties.
For a very long time, scientists have recognized curcumin's potential anti-inflammatory effects. It inhibits the activation of NF-kB, which controls inflammatory genes. It also prevents the production of the inflammatory 5-LOX enzyme while also decreasing COX-2 production. Curcumin inhibits the production of inflammatory cytokines and chemokines like tumor necrosis factor (TNF), interleukin (IL)-1, IL-6, and IL-8.
Curcumin has also been linked to a reduction in amyloid-induced brain inflammation, a hallmark of Alzheimer's disease. Curcumin supplementation in the diet has been suggested as a possible treatment for neurodegenerative diseases like Alzheimer's. Curcumin inhibits amyloid-plaque development in Alzheimer's disease by decreasing cytokine and chemokine activity in peripheral blood monocytes.
The antioxidant and anti-inflammatory properties of curcumin may be useful in preventing and treating cardiovascular disease. For instance, it can restore reduced glutathione, glutathione peroxidase, and superoxide dismutase to normal levels and prevent lipid peroxidation. Myocardial expression of tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-2 (MMP-2) can be suppressed by curcumin, and regulate the expression of eNOS mRNA.
Dr. Rakesh Srivastava is a well-respected endocrinologist and scientist. He has been kind enough to share his insights with practicing physicians and help in the fight against cancer. Please don't hesitate to contact him if you have any queries about your cancer problems. After reading this article, we wish you a thorough understanding of Curcumin and its treatment. Rather than focusing on a quick fix like dieting, you should aim to form healthy habits that will last a lifetime.
Contact: Dr. Rakesh Srivastava
www.rksrivastava.com
Email: contact@glaxhealth.com
Rakesh Srivastava
GLAX, LLC.
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